A team of American researchers have successfully excised HIV DNA from the genomes of living animals to eliminate HIV-1 infection. According to UPI, the team is the first to perform HIV-1 replication and shut down the virus–thus eliminating it from infected cells in three different animal models. One such model includes a “humanized” animal model, where mice were transplanted with human immune cells and infected with HIV. Researchers used the gene-editing technology CRISPR to excise viral fragments from latently infected human cells that were embedded in mouse tissues and organs. The study was published in Molecular Therapy.