At 3 a.m., police responded to a shooting inside the Harlem Nights Bar on Adam Clayton Powell Boulevard.
They found a 22-year-old man shot twice in the back, and a 24-year-old man shot once in the right leg.
Both were taken to Harlem Hospital. The man who had been shot in the back was pronounced dead. The other man is stable.
Police are investigating and no arrests have been made.
Identities of the victims have not been released.