Rapper Big Syke, a longtime friend of Tupac Shakur’s, has died, according to reports.

Syke, 48, was found dead inside his Hawthorne, Calif., home on Monday night with no foul play suspected, TMZ reported.

The artist, born Tyruss Himes, is believed to have died of natural causes, but an official autopsy has yet to be performed. Syke reportedly had a history of obesity and heart issues, according to the gossip site.

The Inglewood, Calif. rapper’s rhymes were featured on some of Tupac’s most popular songs, like “All Eyez on Me,” “Picture me Rollin” and “Check out Time.”

After meeting in 1992, Syke become a member of Tupac’s Thug Life Group, which released one album before calling it quits after Tupac died in Sept. 1996.

Syke also released four albums on his own, including “Be Yo’ Self,” “Big Syke Daddy,” “Street Commando,” and his 2002 self-titled album “Big Syke.”