Hip-hop pioneer Kidd Creole has been charged with murder in the stabbing death of a homeless man found Tuesday night on a Midtown street, police said.

Creole, whose real name is Nathaniel Glover, was arrested Wednesday and was accused of killing a 55-year-old man at the corner of E. 44th St. and Third Ave.

Glover, 57, was one of the members of Grandmaster Flash and the Furious Five, a hip-hop group formed in the South Bronx in the 1970s.

Glover works near the Midtown scene as a handyman and security guard, officials said. Glover had a run-in with the victim, who was drunk, the police source said.

“They had no prior relationship,” the source said. “They had words. Things got out of hand. It was some sort of diss.”

Pedestrians called 911 for the victim just before midnight on Tuesday because they thought he was just passed, cops said.

First responders were surprised to see multiple stab wounds in the man’s chest, police said Wednesday. Medics rushed the victim to Bellevue Hospital Center, where he died.

“There were six people there. All tourists, all trying to help him,” said Van Scott, of Queens. “They thought he was overcome by the heat and then they saw he was stabbed. We just waited for the paramedics to come.”

“He gave some statements and he’s being charged,” the police source said.

The victim — whose name was not released — was homeless and staying at a shelter on the Bowery, police sources said.

Glover was part of a group that introduced rap to a mainstream audience with social commentary hits. The group’s biggest release was a classic called “The Message,” with the famous hook: “Don’t push me ‘cause I’m close to the edge. I’m trying not to lose my head.”